Recent developments in the use of transgenic plants for the production of human therapeutics and biopharmaceuticals
Identifieur interne : 001814 ( Main/Exploration ); précédent : 001813; suivant : 001815Recent developments in the use of transgenic plants for the production of human therapeutics and biopharmaceuticals
Auteurs : Nilesh P. Teli [États-Unis] ; Michael P. Timko [États-Unis]Source :
- Plant Cell, Tissue and Organ Culture [ 0167-6857 ] ; 2004-11-01.
English descriptors
- KwdEn :
Abstract
Abstract: In recent years there has been a dramatic increase in the application of plant biotechnology for the production of a variety of commercially valuable simple and complex biological molecules (biologics) for use in human and animal healthcare. Transgenic whole plants and plant cell culture systems have been developed that have the capacity to economically produce large-scale quantities of antibodies and antibody fragments, antigens and/or vaccine epitopes, metabolic enzymes, hormones, (neuro)peptides and a variety of biologically active complexes and secondary metabolites for direct use as therapeutic agents or diagnostic tools in the medical healthcare industry. As the products of genetically modified plants make their way from concept to commercialization the associated risks and acceptance by the public has been become a focal point. In this paper, we summarize the recent advances made in the use of transgenic plants and plant cell cultures as biological factories for the production of human therapeutics and biopharmaceuticals and discuss the long-term potential of `molecular farming' as a low-cost, efficient method for the production of biological materials with demonstrated utility to the pharmaceutical industry or medical community.
Url:
- https://api.istex.fr/ark:/67375/VQC-WDZZ3DX9-1/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089434
DOI: 10.1007/s11240-004-0653-0
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000586
- to stream Istex, to step Curation: 000553
- to stream Istex, to step Checkpoint: 000282
- to stream Pmc, to step Corpus: 000318
- to stream Pmc, to step Curation: 000318
- to stream Pmc, to step Checkpoint: 000999
- to stream Ncbi, to step Merge: 001751
- to stream Ncbi, to step Curation: 001751
- to stream Ncbi, to step Checkpoint: 001751
- to stream Main, to step Merge: 001825
- to stream Main, to step Curation: 001814
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recent developments in the use of transgenic plants for the production of human therapeutics and biopharmaceuticals</title><author><name sortKey="Teli, Nilesh P" sort="Teli, Nilesh P" uniqKey="Teli N" first="Nilesh P." last="Teli">Nilesh P. Teli</name></author><author><name sortKey="Timko, Michael P" sort="Timko, Michael P" uniqKey="Timko M" first="Michael P." last="Timko">Michael P. Timko</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:344BF381FCC6EBED62CE44FF2E24ADC83DD87BC9</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1007/s11240-004-0653-0</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-WDZZ3DX9-1/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000586</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000586</idno><idno type="wicri:Area/Istex/Curation">000553</idno><idno type="wicri:Area/Istex/Checkpoint">000282</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000282</idno><idno type="wicri:doubleKey">0167-6857:2004:Teli N:recent:developments:in</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089434</idno><idno type="RBID">PMC:7089434</idno><idno type="wicri:Area/Pmc/Corpus">000318</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000318</idno><idno type="wicri:Area/Pmc/Curation">000318</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000318</idno><idno type="wicri:Area/Pmc/Checkpoint">000999</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000999</idno><idno type="wicri:Area/Ncbi/Merge">001751</idno><idno type="wicri:Area/Ncbi/Curation">001751</idno><idno type="wicri:Area/Ncbi/Checkpoint">001751</idno><idno type="wicri:doubleKey">0167-6857:2004:Teli N:recent:developments:in</idno><idno type="wicri:Area/Main/Merge">001825</idno><idno type="wicri:Area/Main/Curation">001814</idno><idno type="wicri:Area/Main/Exploration">001814</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Recent developments in the use of transgenic plants for the production of human therapeutics and biopharmaceuticals</title><author><name sortKey="Teli, Nilesh P" sort="Teli, Nilesh P" uniqKey="Teli N" first="Nilesh P." last="Teli">Nilesh P. Teli</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, University of Virginia, Gilmer Hall 044, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Timko, Michael P" sort="Timko, Michael P" uniqKey="Timko M" first="Michael P." last="Timko">Michael P. Timko</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, University of Virginia, Gilmer Hall 044, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Plant Cell, Tissue and Organ Culture</title><title level="j" type="sub">An International Journal on Biotechnology of Higher Plants</title><title level="j" type="abbrev">Plant Cell, Tissue and Organ Culture</title><idno type="ISSN">0167-6857</idno><idno type="eISSN">1573-5044</idno><imprint><publisher>Kluwer Academic Publishers</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="2004-11-01">2004-11-01</date><biblScope unit="volume">79</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="125">125</biblScope><biblScope unit="page" to="145">145</biblScope></imprint><idno type="ISSN">0167-6857</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0167-6857</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>edible vaccines</term><term>molecular farming</term><term>plantibodies</term><term>secondary metabolites</term><term>therapeutic proteins</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: In recent years there has been a dramatic increase in the application of plant biotechnology for the production of a variety of commercially valuable simple and complex biological molecules (biologics) for use in human and animal healthcare. Transgenic whole plants and plant cell culture systems have been developed that have the capacity to economically produce large-scale quantities of antibodies and antibody fragments, antigens and/or vaccine epitopes, metabolic enzymes, hormones, (neuro)peptides and a variety of biologically active complexes and secondary metabolites for direct use as therapeutic agents or diagnostic tools in the medical healthcare industry. As the products of genetically modified plants make their way from concept to commercialization the associated risks and acceptance by the public has been become a focal point. In this paper, we summarize the recent advances made in the use of transgenic plants and plant cell cultures as biological factories for the production of human therapeutics and biopharmaceuticals and discuss the long-term potential of `molecular farming' as a low-cost, efficient method for the production of biological materials with demonstrated utility to the pharmaceutical industry or medical community.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Virginie</li></region></list><tree><country name="États-Unis"><region name="Virginie"><name sortKey="Teli, Nilesh P" sort="Teli, Nilesh P" uniqKey="Teli N" first="Nilesh P." last="Teli">Nilesh P. Teli</name></region><name sortKey="Timko, Michael P" sort="Timko, Michael P" uniqKey="Timko M" first="Michael P." last="Timko">Michael P. Timko</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001814 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001814 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:344BF381FCC6EBED62CE44FF2E24ADC83DD87BC9
|texte= Recent developments in the use of transgenic plants for the production of human therapeutics and biopharmaceuticals
}}
| This area was generated with Dilib version V0.6.33. |  |